Explorer asks for Internet Access

I think my computer is infected with something
My Explorer.exe asks for internet access

I've Avast installed on my PC Fully updated
Also Zone alarm Security Suite Fully Updated
Spybot S&D Fully Updated
Ad-Aware Fully Updated
Spyware Doctor Fully Updated
Microsoft Antispyware Fully Updated

I detected the infection yesterday when my explorer asked for internet access
We'll I denied it but even afetr scanning with all the things above nothing
was detected

Anyone who can help
Any news of recent outbreak
Any suggestion