Mention exact system specs(processor & mobo model).Also mention how these two WD hdd were connected before & working.
Win ISO size has no relation with GPT/MBR,I think you are confusing it with NTFS/FAT32(FAT doesn't support files larger than 4gb).
Processor:-
Name
Intel Core 2 Quad Q9550
Codename Yorkfield
Specification Intel(R) Core(TM)2 Quad CPU Q9550 @ 2.83GHz
Package (platform ID) Socket 775 LGA (0x4)
Mother Board: Intel® Desktop Board DP45SG
Northbridge Intel P45/P43/G45/G43 rev. A2
Southbridge Intel 82801JR (ICH10R) rev. 00
Graphics Interface PCI-Express
PCI-E Link Width x16
PCI-E Max Link Width x16
Memory Type DDR3
Memory Size 8 GBytes
Channels Dual, (Symmetric)
Memory Frequency 666.7 MHz (1:2)
When ever connect two Hardisk... Always some issues like some times will detect or some starting issues or freezing.
So I disconnect one use as external through hardisk casing