tried deleting that file via safemode ?
Me too got affected by that earlier............use Avira/AVG to delete that......If not then try deleting in safe mode........
Better option is back it up and format
It's a trojan, disable 'Hide System files' and delete the autorun.inf and whatever exe file is there. Also, do the same for all the partitions o your hard disk.
Open your registry: Run ->regedit, then:
Open registry, goto HKEY_LOCAL_MACHINE, Software, Microsoft, Windows, CurrentVersion, Run. See if any values exist for the vbs file and remove them.
Repeat for RunOnce, RunOnceEx.
Next goto HKEY_LOCAL_MACHINE, SOftware, Microsoft, WindowsNT, CurrentVersion, WinLogon and remove any keys which have the vbs file as reference.
Do this in safe mode.
Link: NewVirusRemoval.vbs: USB drive not opening? Here is a workaround[my blog]
Also look for the comment by Pallab